Simultaneous Quantitation of a Novel α1/β1-Blocker TJ0711 and Its Two Metabolites in Dog Plasma Using LC-MS/MS and Its Application to a Pharmacokinetic Study after Intravenous Infusion

TJ0711∙HCl, which is a novel α1/β1 adrenoceptor blocking agent with a ratio of 1:1 for α1/β1, is designed to treat and prevent perioperative hypertension. M1 and M3 were identified as important metabolites in vitro for either antihypertension activity or the major metabolite pr...

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Principais autores:	Wenwen Zhu, Wanyu Liu, Haojv Li, Guojia Xu, Qian Li, Jiangeng Huang, Gao Li, Luqin Si
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-01-01
coleção:	Pharmaceutics
Assuntos:	TJ0711 LC-MS/MS pharmacokinetics metabolite beagle dog
Acesso em linha:	http://www.mdpi.com/1999-4923/11/1/38
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