A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice

An understanding of recombinant adeno-associated virus (AAV) biodistribution profiles is an important element of a preclinical development program. Here, we have developed a radiolabeling strategy utilizing the co-delivery of 125I (non-residualizing) and 111In (residualizing) radionuclide-conjugated...

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Principais autores:	Hongzhi Wang, Ran Li, Shraddha Sadekar, Amrita V. Kamath, Ben-Quan Shen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-09-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	adeno-associated virus AAV capsid biodistribution radiolabeling cellular uptake pharmacokinetics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050124001426
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