In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells

Abstract Background Hypothalamic kisspeptin neurons are master regulators of reproduction in mammals, including humans and rodents, via direct stimulation of gonadotropin-releasing hormone (GnRH) neurons. Therefore, they play a central role in puberty onset and gonadal function in mammals. Arcuate k...

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Detalhes bibliográficos

Principais autores:	Natsuki Miyake, Hidetaka Suga, Satoko Osuka, Tomomi Seki, Reina Sonehara, Ayako Muraoka, Tomoko Nakamura, Bayasula, Tsutomu Miwata, Mika Soen, Mayu Sakakibara, Shiori Go, Saki Hasegawa, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Hiroshi Arima, Hiroaki Kajiyama
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Reproductive Biology and Endocrinology
Assuntos:	KNDy neurons Hypothalamic–pituitary–gonadal (HPG) axis Embryonic stem cells In vitro differentiation
Acesso em linha:	https://doi.org/10.1186/s12958-026-01536-x
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