Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsiveness in mycobacterial diseases

<p>Background</p> <p>Advanced stages of leprosy show T cell unresponsiveness and lipids of mycobacterial origin are speculated to modulate immune responses in these patients. Present study elucidates the role of phenolicglycolipid (PGL-1) and Mannose-capped lipoarabinomannan (Man-LAM) on TCR- and TC...

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Автори:	Dagur Pradeep, Sharma Bhawna, Upadhyay Rajni, Dua Bhavyata, Rizvi Arshad, Khan Naim, Katoch Vishwa, Sengupta Utpal, Joshi Beenu
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2012-09-01
Серія:	Lipids in Health and Disease
Предмети:	Mycobacteria PGL-1 Man-LAM T-cell activation Anergy
Онлайн доступ:	http://www.lipidworld.com/content/11/1/119
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