The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair
Abstract Microglia are critical regulators of neuroinflammation and neurodegeneration. Haploinsufficiency of C9orf72, the most frequently mutated gene in amyotrophic lateral sclerosis and frontotemporal dementia, has been linked to autophagy-lysosomal pathway defects, but the role of C9orf72 in micr...
Na minha lista:
| Principais autores: | , , , , , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer Nature
2026-05-01
|
| Serier: | The EMBO Journal |
| Online adgang: | https://doi.org/10.1038/s44318-026-00817-w |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|