Restoration of p53 Expression in Human Cancer Cell Lines Upregulates the Expression of Notch1: Implications for Cancer Cell Fate Determination after Genotoxic Stress

Following genotoxic stress, transcriptional activation of target genes by p53 tumor suppressor is critical in cell fate determination. Here we report that the restoration of p53 function in human cancer cell lines that are deficient in p53 function upregulated the expression of Notch1. Interestingly...

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Detaylı Bibliyografya

Asıl Yazarlar:	Fatouma Alimirah, Ravichandran Panchanathan, Francesca J. Davis, Jianming Chen, Divaker Choubey
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Elsevier 2007-05-01
Seri Bilgileri:	Neoplasia: An International Journal for Oncology Research
Konular:	p53 Notch transcription DNA damage apoptosis
Online Erişim:	http://www.sciencedirect.com/science/article/pii/S1476558607800935
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