TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitro

Glioblastoma (GBM) is fatal and the study of therapeutic resistance, disease progression, and drug discovery in GBM or glioma stem cells is often hindered by limited resources. This limitation slows down progress in both drug discovery and patient survival. Here we present a genetically engineered h...

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Autors principals:	Sanjay K. Singh, Yan Wang, Ahmed Habib, Mamindla Priyadarshini, Chowdari V. Kodavali, Apeng Chen, Wencai Ma, Jing Wang, N. U. Farrukh Hameed, Baoli Hu, Gregory N. Fuller, Scott M. Kulich, Nduka Amankulor, Rivka R. Colen, Lincoln A. Edwards, Pascal O. Zinn
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-10-01
Col·lecció:	Frontiers in Oncology
Matèries:	organoid nestin glioblastoma TP53 PTEN and NF1 tumor suppressors
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1279806/full
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