GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy
Abstract Background Ligand-dependent activation of the G-protein coupled receptor 119 (GPR119) lowers blood glucose via glucose-dependent insulin secretion and intestinal glucagon-like peptide-1 production. However, the function of GPR119 in cancer cells has not been studied. Methods GPR119 expressi...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMC
2018-11-01
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| Schriftenreihe: | Journal of Experimental & Clinical Cancer Research |
| Schlagworte: | |
| Online-Zugang: | http://link.springer.com/article/10.1186/s13046-018-0949-2 |
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