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METTL3 facilitates renal cell carcinoma progression by PLOD2 m6A-methylation under prolonged hypoxia

Abstract N6-methyladenosine (m6A) is the most prevalent reversible modification in eukaryotic mRNA, and it plays a critical role in tumor progression. The purpose of this study was to investigate the function and regulatory mechanisms of the methyltransferase METTL3 in renal cell carcinoma (RCC). ME...

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Bibliografische gegevens
Hoofdauteurs: Yimeng Chen, Yichen He, Zhengsheng Li, Nan Zhang, Cuixing Zhou, Xiaozhou He, Dong Xue
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2024-01-01
Reeks:Cell Death and Disease
Online toegang:https://doi.org/10.1038/s41419-023-06411-w
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