Preparation of alpha-2 macroglobulin–rich plasma from human blood—technique and compositional analysis of plasma, platelet-rich plasma, platelet-poor plasma, and alpha-2 macroglobulin–rich plasma

Introduction: Alpha-2 macroglobulin (A2M) has been identified as an inhibitor of matrix metalloproteinases, interleukin-1β and other factors that contribute to post-traumatic osteoarthritis. The therapeutic use of intra-articular A2M requires a standardized protocol for its preparation, coupled with...

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Autors principals:	Kelly K. Showel, Christopher H. Evans, Rodolfo E. De la Vega, Gresin P. Hawse, Karina Gonzalez Carta, Daniël B.F. Saris, Jacob L. Sellon, Brennan J. Boettcher
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-12-01
Col·lecció:	Journal of Cartilage & Joint Preservation
Matèries:	Alpha-2 macroglobulin Biologic therapy Cytokine Osteoarthritis Platelet-poor plasma Platelet-rich plasma
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S266725452500023X
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