Glucosamine induces hepatic FGF21 expression by activating the Akt/mTOR/p70S6K axis and driving PGC-1α activity

Abstract Glucosamine (GlcN) is a common supplement used to alleviate osteoarthritis, but it may dysregulate glucose tolerance and induce insulin resistance, thereby increasing metabolic burden. The liver is a vital organ that modulates the Akt/mTOR/p70S6K signaling pathway in response to growth and...

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Hauptverfasser:	Shui-Yu Liu, Luen-Kui Chen, Pin-Hsuan Li, Guan-Lin Wu, Tsung-Hui Wu, Yuan-Bin Yu, Heng-Fu Lin, Chi-Chang Juan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-04-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Glucosamine Diabetes Hepatocyte FGF21 PGC-1α
Online-Zugang:	https://doi.org/10.1038/s41598-025-96249-3
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