SMΝΔ7 mice show breathing and airflow defects with significant pathology of respiratory and oral tract tissues

IntroductionSpinal muscular atrophy (SMA) is a neurodegenerative disorder caused by SMN1 mutations, leading to SMN protein deficiency and motor neuron loss. While progressive weakness, respiratory defects, and oral dysfunction are well-documented in patients, the underlying pathophysiology of breath...

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Principais autores:	Roxanne Muchow, Michelle Woolridge, Catherine L. Smith, F. Javier Llorente Torres, Dennis Perez-Lopez, Nicole L. Nichols, Monique A. Lorson, Christian L. Lorson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	histology neuromuscular disease plethysmography respiration spinal muscular atrophy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fncel.2026.1844362/full
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