Time-dependent modulation of FXR and Nrf2 signaling in rat models of BDL-induced cholestasis

Objective(s): Farnesoid X receptor (FXR) and nuclear factor erythroid 2-related factor 2 (Nrf2) protect the liver against cholestatic injury by regulating antioxidant and anti-inflammatory pathways. Bile duct ligation (BDL) is a standard model for studying cholestatic liver disease, yet the temporal...

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Principais autores:	Seyed Ebrahim Daryabari, Elmira Jafari Afshar, Azadeh Khalili, Seyed Ali Hashemi, Parham Samimisedeh, Gholamreza Bayat, Hossein Karim
Format:	Artigo
Jezik:	Inglês
Izdano:	Mashhad University of Medical Sciences 2026-07-01
Serija:	Iranian Journal of Basic Medical Sciences
Teme:	bile duct ligation (bdl) cholestasis cholestatic liver injury farnesoid x receptor nuclear factor erythroid 2-related factor 2
Online dostop:	https://ijbms.mums.ac.ir/article_27720_0a4f55ab5e32ca75a07d601a5f0aed63.pdf
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