HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly

Abstract The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions are mediated by two positively charged rings created...

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Bibliografiske detaljer

Principais autores:	Alex Kleinpeter, Donna L. Mallery, Nadine Renner, Anna Albecka, J. Ole Klarhof, Eric O. Freed, Leo C. James
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2024-09-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-024-51971-w
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