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Structure-Function Relationship of the Ryanodine Receptor Cluster Network in Sinoatrial Node Cells

The rate of spontaneous action potentials (APs) generated by sinoatrial node cells (SANC) is regulated by local Ca<sup>2+</sup> release (LCR) from the sarcoplasmic reticulum via Ca<sup>2+</sup> release channels (ryanodine receptors, RyRs). LCR events propagate and self-organize within the network of...

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Principais autores: Alexander V. Maltsev, Valeria Ventura Subirachs, Oliver Monfredi, Magdalena Juhaszova, Pooja Ajay Warrier, Shardul Rakshit, Syevda Tagirova, Anna V. Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-11-01
coleção:Cells
Assuntos:
β adrenergic stimulation
numerical model
pacemaker function
ryanodine receptor
sinoatrial node
Acesso em linha:https://www.mdpi.com/2073-4409/13/22/1885
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