Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records

Abstract Background Vasomotor symptoms (VMS) can often significantly impact women’s quality of life at menopause. In vivo studies have shown that increased neurokinin B (NKB) / neurokinin 3 receptor (NK3R) signalling contributes to VMS, with previous genetic studies implicating the TACR3 gene locus...

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Hauptverfasser:	Katherine S. Ruth, Robin N. Beaumont, Jonathan M. Locke, Jessica Tyrrell, Carolyn J. Crandall, Gareth Hawkes, Timothy M. Frayling, Julia K. Prague, Kashyap A. Patel, Andrew R. Wood, Michael N. Weedon, Anna Murray
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-10-01
Schriftenreihe:	BMC Medical Genomics
Schlagworte:	Vasomotor symptoms Menopause Hormone replacement therapy Genome-wide analyses Genome-wide association study
Online-Zugang:	https://doi.org/10.1186/s12920-023-01658-w
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