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High glucose augments angiotensinogen in human renal proximal tubular cells through hepatocyte nuclear factor-5.

High glucose has been demonstrated to induce angiotensinogen (AGT) synthesis in the renal proximal tubular cells (RPTCs) of rats, which may further activate the intrarenal renin-angiotensin system (RAS) and contribute to diabetic nephropathy. This study aimed to investigate the effects of high gluco...

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Autores principales: Juan Wang, Yuki Shibayama, Hiroyuki Kobori, Ya Liu, Hideki Kobara, Tsutomu Masaki, Zhiyu Wang, Akira Nishiyama
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2017-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC5650141?pdf=render
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