Genetic risk and clinical implications of BRCA1 and BRCA2 mutations in Turkish triple-negative breast cancer patients

Abstract Background Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Genetic mutations, particularly in BRCA1 and BRCA2, significantly influence its pathogenesis and clinical outcomes. Th...

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Detalhes bibliográficos

Principais autores:	Betul Celik Demirbas, Seda Kilic Erciyas, Ozge Sukruoglu Erdogan, Zubeyde Yalniz Kayim, Ozge Pasin, Merve Cigdem Ozgel, Seref Bugra Tuncer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2025-09-01
coleção:	Discover Oncology
Assuntos:	BRCA1 and BRCA2 mutations Triple-negative breast cancer Genetic predisposition
Acesso em linha:	https://doi.org/10.1007/s12672-025-03470-7
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