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CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis

Osteoarthritis (OA) shows various clinical manifestations depending on the status of its joint components. We aimed to identify the synovial cell subsets responsible for OA pathophysiology by comprehensive analyses of human synovium samples in single-cell resolution. Two distinct OA synovial tissue...

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Principais autores: Junya Miyahara, Yasunori Omata, Ryota Chijimatsu, Hiroyuki Okada, Hisatoshi Ishikura, Junya Higuchi, Naohiro Tachibana, Kosei Nagata, Shoichiro Tani, Kenichi Kono, Kohei Kawaguchi, Ryota Yamagami, Hiroshi Inui, Shuji Taketomi, Yasuhide Iwanaga, Asuka Terashima, Fumiko Yano, Masahide Seki, Yutaka Suzuki, Roland Baron, Sakae Tanaka, Taku Saito
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2025-01-01
Serier:JCI Insight
Fag:
Bone biology
Inflammation
Online adgang:https://doi.org/10.1172/jci.insight.183690
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