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Evolution of intrinsically disordered regions in vertebrate galectins for phase separation

Abstract Intrinsically disordered regions (IDRs) are widespread in proteins, yet their evolutionary paths remain poorly understood. Using galectin, a universal carbohydrate-binding protein, we investigated how IDRs evolved and acquired their biological roles in vertebrates. Through extensive proteom...

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Autors principals: Yu-Hao Lin, Yu-Chen Chen, Yung-Chen Sun, Jie-rong Huang
Format: Artigo
Idioma:Inglês
Publicat: Springer Nature 2026-02-01
Col·lecció:EMBO Reports
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Accés en línia:https://doi.org/10.1038/s44319-026-00692-w
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