Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a neurodegenerative disease characterized by intraneuronal Lewy Body (LB) aggregates composed of misfolded alpha-synuclein (α-syn). The spread of misfolded α-syn follows a typical pattern: starting in the olfactory bulb (OB) and the gut, this pathology...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Haichen Niu, Lingyu Shen, Tongzhou Li, Chao Ren, Sheng Ding, Lei Wang, Zhonghai Zhang, Xiaoyu Liu, Qiang Zhang, Deqin Geng, Xiujuan Wu, Haiying Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2018-09-01
Serie:	Translational Neurodegeneration
Soggetti:	Alpha-synuclein Prodromal animal model Parkinson’s disease Olfactory bulb Autophagy
Accesso online:	http://link.springer.com/article/10.1186/s40035-018-0128-6
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!