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Inhibition of Cyclin D1 Expression in Human Glioblastoma Cells is Associated with Increased Temozolomide Chemosensitivity

Background/Aims: Cyclin D1 (CCND1) is frequently overexpressed in malignant gliomas. We have previously shown ectopic overexpression of CCND1 in human malignant gliomas cell lines. Methods: Quantitative reverse transcriptase PCR (qRT-PCR) and Western Blot (WB) was performed to investigate the expres...

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Principais autores: Danfeng Zhang, Dawei Dai, Mengxia Zhou, Zhenxing Li, Chunhui Wang, Yicheng Lu, Yiming Li, Junyu Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2018-12-01
coleção:Cellular Physiology and Biochemistry
Assuntos:
Glioblastoma
Chemoresistance
Temozolomide
CCND1
MDR1
Acesso em linha:https://www.karger.com/Article/FullText/495920
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