Acetylcysteine modulates sphingolipid levels by inhibiting neutral sphingomyelinase during aging in rat tissues

Old-age-associated pathologies usually coincide with altered sphingolipid metabolism. Changes in the level of sphingomyelin (SM) and ceramide are largely determined by the activation of neutral sphingomyelinase (nSMase) during aging. nSMase is a key enzyme in sphingolipid turnover; it generates cera...

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Detalles Bibliográficos

Principais autores:	Loay Khaled Hassouneh, Salameh Odatallah Aldajah, Manal Mamdouh Najdawi, Zead Helmi Abudayeh, Qais Ibrahim Abualassal, Amajad Naji aburmelah, Alaa Yahya Sirhan
Formato:	Artigo
Idioma:	Inglês
Publicado:	Polskie Towarzystwo Farmaceutyczne 2023-04-01
Series:	Acta Poloniae Pharmaceutica
Assuntos:	aging n-acetylcysteine ceramide sphingomyelin neutral sphingomyelinase
Acceso en liña:	https://www.ptfarm.pl/download/?file=File%2FActa_Poloniae%2F2023%2F1%2F045.pdf
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