A high‐throughput RNAi screen for detection of immune‐checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes

Abstract The success of T cell‐based cancer immunotherapy is limited by tumor's resistance against killing by cytotoxic T lymphocytes (CTLs). Tumor‐immune resistance is mediated by cell surface ligands that engage immune‐inhibitory receptors on T cells. These ligands represent potent targets for the...

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Autors principals:	Nisit Khandelwal, Marco Breinig, Tobias Speck, Tillmann Michels, Christiane Kreutzer, Antonio Sorrentino, Ashwini Kumar Sharma, Ludmila Umansky, Heinke Conrad, Isabel Poschke, Rienk Offringa, Rainer König, Helga Bernhard, Arthur Machlenkin, Michael Boutros, Philipp Beckhove
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2015-02-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	cancer immunotherapy immune suppression RNAi screen
Accés en línia:	https://doi.org/10.15252/emmm.201404414
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