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Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV

BACKGROUND NK cell function is impaired in people with HIV (PWH), hindering their potential to reduce the lymphoid tissue (LT) reservoir. The IL-15 superagonist N-803 has been shown to enhance NK and T cell function and thus may reduce viral reservoirs.METHODS To determine the impact of N-803 on LTs...

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Hoofdauteurs: Joshua Rhein, Jeffrey G. Chipman, Gregory J. Beilman, Ross Cromarty, Kevin Escandón, Jodi Anderson, Garritt Wieking, Jarrett Reichel, Rodolfo Batres, Alexander Khoruts, Christopher M. Basting, Peter Hinderlie, Zachary B. Davis, Anne Eaton, Byron P. Vaughn, Elnaz Eilkhani, Jeffrey T. Safrit, Patrick Soon-Shiong, Jason V. Baker, Nichole R. Klatt, Steven G. Deeks, Jeffrey S. Miller, Timothy W. Schacker
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical investigation 2025-07-01
Reeks:JCI Insight
Onderwerpen:
AIDS/HIV
Infectious disease
Online toegang:https://doi.org/10.1172/jci.insight.190831
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