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Combined treatment of 3-hydroxypyridine-4-one derivatives and green tea extract to induce hepcidin expression in iron-overloaded β-thalassemic mice

Objective: To evaluate the efficacy of deferiprone (DFP), 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) or green tea extract (GTE) in enhancing expression of hepatic hepcidin1 (Hamp1) mRNA and relieving iron overload in β-globin knockout thalassemic mice. Methods: The β-globin knoc...

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Principais autores: Supranee Upanan, Kanjana Pangjit, Chairat Uthaipibull, Suthat Fucharoen, Andrew T. McKie, Somdet Srichairatanakool
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Medknow Publications 2015-12-01
coleção:Asian Pacific Journal of Tropical Biomedicine
Assuntos:
Thalassemia
Iron overload
Hepcidin
Iron chelator
Green tea
Hydroxypyridinone
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2221169115002191
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