Computational Modeling, Docking, Synthesis, Characterization, and in vitro Cyclooxygenase Inhibitory Activity of Some Novel Non-Steroidal Anti-inflammatory Prodrugs

   Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most prescribed analgesic and anti-inflammatory drugs. However, inhibition of cyclooxygenase1 and acidic groups such as carboxylic groups in most NSAIDs cause gastrointestinal (GI) side effects. Therefore, masking the acidic groups til...

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Hauptverfasser:	Dana Muhammad Hamad Ameen, Sara Ramzi Abdulhameed
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Salahaddin University-Erbil 2020-12-01
Schriftenreihe:	Zanco Journal of Pure and Applied Sciences
Schlagworte:	NSAIDs; docking; prodrug; cyclooxygenase; acetamide.
Online-Zugang:	https://zancojournal.su.edu.krd/index.php/JPAS/article/view/2509
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