Generation of Mouse Model of Hemophilia A by Introducing Novel Mutations, Using CRISPR/Nickase Gene Targeting System

Developing mouse models of hemophilia A has been shown to facilitate in vivo studies to explore the probablemechanism(s) underlying the disease and to examine the efficiency of the relevant potential therapeutics. This studyaimed to knockout (KO) the coagulation factor viii (fviii) gene in NMRI mice...

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Principais autores:	Mehdi Shamsara, Abbas Jamshidizad, Aidin Rahim-Tayefeh, Maliheh Davari, Ali Rajabi Zangi, Fatemeh Masoumi, Alireza Zomorodipour
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Royan Institute (ACECR), Tehran 2023-09-01
Colecção:	Cell Journal
Assuntos:	crispr-cas9 factor viii hemophilia a knockout gene mouse models
Acesso em linha:	https://www.celljournal.org/article_705505_27aeb300fbfc88bb89c5dce7a7ca5d3a.pdf
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