PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis

Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers. Here, using an integrative approach, we have dissected the metabolic fingerprints of lung adenocarcinomas, and we show...

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Détails bibliographiques

Auteurs principaux:	Boxi Zhang, Adi Zheng, Per Hydbring, Gorbatchev Ambroise, Amanda Tomie Ouchida, Michel Goiny, Helin Vakifahmetoglu-Norberg, Erik Norberg
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2017-06-01
Collection:	Cell Reports
Sujets:	tumor metabolism metabolic heterogeneity lung cancer PHGDH serine DNA damage pyrimidines purines lung adenocarcinoma metabolomics
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2211124717307246
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