Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy

Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not bee...

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Autores principales:	Nicola Principe, Joel Kidman, Siting Goh, Caitlin M. Tilsed, Scott A. Fisher, Vanessa S. Fear, Catherine A. Forbes, Rachael M. Zemek, Abha Chopra, Mark Watson, Ian M. Dick, Louis Boon, Robert A. Holt, Richard A. Lake, Anna K. Nowak, Willem Joost Lesterhuis, Alison M. McDonnell, Jonathan Chee
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2020-11-01
Colección:	Frontiers in Immunology
Materias:	immune checkpoint therapy tumor-specific T cells TCR repertoire cytotoxic T lymphocytes effector memory
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.584423/full
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