Glymphatic system dysfunction mediates amyloid deposition and cognitive impairment in Alzheimer’s disease: a PET/MRI multimodality imaging study

Abstract Background Abnormal glymphatic system may play a critical role in amyloid-β (Aβ) accumulation in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients. This study aims to use diffusion tensor image analysis along the perivascular space (DTI-ALPS) and perivascular space volum...

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Principais autores:	Hanxiao Xue, Sheng Bi, Zhigeng Chen, Yujie He, Wenqi Xu, Xiaoyin Xu, Bixiao Cui, Yujie Hu, Zhigang Qi, Shaozhen Yan, Jie Lu
Formato:	Artigo
Idioma:	Inglês
Publicado:	SpringerOpen 2025-11-01
Series:	EJNMMI Research
Assuntos:	Alzheimer’s disease Glymphatic system Amyloid imaging PET/MRI DTI-ALPS Perivascular space
Acceso en liña:	https://doi.org/10.1186/s13550-025-01339-y
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