TadA orthologs enable both cytosine and adenine editing of base editors

Properties of cytidine and adenosine deaminases lead to off-target effects for cytosine base editors (CBEs) and adenine base editors (ABEs). Here the authors report that 25 TadA orthologs could be engineered to generate functional ABEs, CBEs or ACBEs via single/double mutations with minimised off-ta...

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主要な著者:	Shuqian Zhang, Bo Yuan, Jixin Cao, Liting Song, Jinlong Chen, Jiayi Qiu, Zilong Qiu, Xing-Ming Zhao, Jingqi Chen, Tian-Lin Cheng
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2023-01-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-023-36003-3
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