Transepidermal Delivery of Calcium Hydroxyapatite (CaHA) Microneedling: A Novel Approach for Inducing Collagen Types III and IV

<b>Background/Objectives:</b> Microneedling is increasingly applied to enhance transepidermal drug delivery. Calcium hydroxyapatite (CaHA) has recognized biostimulatory properties, but its delivery and distribution within the dermis remain poorly characterized. This study aimed to evaluate the effic...

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Principais autores:	Andréia Luiza Oliveira Costa, Fernando Veloso Caldeira Barcellos, Maria Tereza Scardua Mariano, Eloá Mangabeira Santos, Lorena dos Reis Pereira Queiroz, Erivelton Pereira Santos, Vitória Regina Oliveira de Melo, Sérgio Henrique Sousa Santos, Lucyana Conceição Farias, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2025-10-01
Series:	Biomedicines
Assuntos:	microneedling transepidermal delivery calcium hydroxyapatite (CaHA) extracellular matrix remodeling collagen expression hyaluronidase
Acceso en liña:	https://www.mdpi.com/2227-9059/13/10/2463
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