DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation
Abstract Viral infection activates the transcription factors IRF3 and NF-κB, which induce type I interferon (IFN) and antiviral innate immune responses. Here, we identify dual-specific tyrosine phosphorylation-regulated kinase 4 (DYRK4) as an important regulator of virus-triggered IFN-β induction an...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Nature
2024-12-01
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| Schriftenreihe: | EMBO Reports |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1038/s44319-024-00352-x |
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