Hypusination of the translation factor eIF5A regulates mitochondrial tRNA processing to promote prostate cancer aggressiveness

Abstract Protein synthesis plays a central role in cancer development and progression. eukaryotic initiation factor 5 A (eIF5A), a translation factor activated by hypusination, is implicated in tumorigenesis, however, its mode of action is still unclear. We find that hypusinated eIF5A (eIF5Ahyp) pro...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Michel Kahi, Abigail Mazzu′, Ludovic Batistic, Marc Pujalte-Martin, Victor Tiroille, Anne Vincent, Joseph Murdaca, Loic Trapani, Paraskevi Kousteridou, Oumayma Benaceur, Amine Belaid, Marie Irondelle, Emilie Thomas, Christelle Boscagli, Pierre Bertrand, Heather S. Carr, Frédéric Larbret, Emilie Baudelet, Stéphane Audebert, Didier F. Pisani, Silvère Baron, Luc Camoin, Mathieu Carlier, Matthieu Durand, Damien Ambrosetti, Yu Chen, Jean-Jacques Diaz, Arnaud Jacquel, Issam Ben-Sahra, Nathalie M. Mazure, Pascal Peraldi, Frédéric Bost
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-03-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-70566-1
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!