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Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy

Venetoclax and obinutuzumab are becoming frontline therapies for chronic lymphocytic leukemia (CLL) patients. Unfortunately, drug resistance still occurs, and the combination could be immunosuppressive. Lysosomes have previously been identified as a target for obinutuzumab cytotoxicity in CLL cells,...

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Principais autores: Madhumita S. Manivannan, Xiaoyan Yang, Nirav Patel, Anthea Peters, James B. Johnston, Spencer B. Gibson
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-06-01
Serier:Cells
Fag:
CLL
lysosomes
cell death
cathepsins
autophagy
Online adgang:https://www.mdpi.com/2073-4409/13/12/1041
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