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A multi-analyte liquid biopsy approach for nonseminomatous testicular germ cell tumors: combining cfDNA and N-glycan analysis in blood and seminal plasma

Abstract Background Nonseminomatous testicular germ cell tumors (NSE) present significant diagnostic challenges, especially for the early detection of serum tumor marker (STM) negative cases. Current diagnostic tools are limited, highlighting the need for innovative approaches. This study investigat...

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Principais autores: Jure Krasic, Dinko Soic, Lucija Skara Abramovic, Ivona Kolosnjaj, Miroslav Tomic, Alen Vrtaric, Sasa Kralik Oguic, Nina Gelo, Ana Katusic Bojanac, Davor Jezek, Dinko Mitrecic, Monika Ulamec, Tomislav Kulis, Olga Gornik, Nino Sincic
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-07-01
Serier:Cancer Cell International
Fag:
Cell-free DNA
N-glycosylation
Epigenetics
Biomarkers
Testicular germ cell tumors
Semen quality
Online adgang:https://doi.org/10.1186/s12935-025-03887-8
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