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Differential requirements for Gli2 and Gli3 in the regional specification of the mouse hypothalamus

Secreted protein Sonic hedgehog (Shh) ventralizes the neural tube by modulating the crucial balance between activating and repressing functions (GliA, GliR) of transcription factors Gli2 and Gli3. This balance—the Shh-Gli code—is species- and context-dependent and has been elucidated for the mouse s...

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Main Authors: Roberta eHaddad-Tóvolli, Fabian ePaul, Yuanfeng eZhang, Xunlei eZhou, Thomas eTheil, Luis ePuelles, Sandra eBlaess, Gonzalo eAlvarez-Bolado
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Neuroanatomy
Subjects:
Hypothalamus
Mouse
Gli3
Shh
embryo
Gli2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00034/full
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