The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5′-3′ XRN1-mediated RNA decay pathway in the replication complexes

Abstract Background The zinc finger protein 36-like (ZFP36L) family is a CCCH-type group consisting of RNA-binding proteins, i.e., ZFP36L1 and ZFP36L2, which regulate cellular mRNA through the RNA decay pathway. ZFP36L1 combats flavivirus infections through the 5′-3′ XRN1 and 3′-5′ RNA exosome decay...

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Principais autores:	Ren-Jye Lin, Li-Hsiung Lin, Zih-Ping Chen, Bing-Cheng Liu, Pin-Chen Ko, Ching-Len Liao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
Colecção:	Journal of Biomedical Science
Assuntos:	CCCH-type zinc finger protein ZFP36L2 5′- 3′ XRN1 Antiviral mechanism Processing bodies Replication complexes
Acesso em linha:	https://doi.org/10.1186/s12929-025-01122-0
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