Cryo-EM structures of Nipah virus polymerases and high-throughput RdRp assay development enable anti-NiV drug discovery

Abstract Transcription and replication of the Nipah virus (NiV) are driven by the large protein (L) together with its essential co-factor phosphoprotein (P). L encodes all the viral enzymatic functions, including RNA-dependent RNA polymerase (RdRp) activity, while the tetrameric P is multi-modular....

Popoln opis

Bibliografske podrobnosti

Principais autores:	Zhenhang Chen, Jeanne Quirit Dudley, Colin Deniston, Cosmo Z. Buffalo, Debjani Patra, Dongdong Cao, Julia Hunt, Ahmed Rohaim, Debapriya Sengupta, Lan Wen, Tiffany Tsang, Lili Xie, Michael DiDonato, Glen Spraggon, Matthew C. Clifton, Nadine Jarrousse, Judith Straimer, Bo Liang
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-07-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-025-61764-4
Oznake:	Označite Brez oznak, prvi označite!