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Blood-brain barrier dysfunction in cerebral arteriovenous malformations. A murine model of hypoperfusion-reperfusion injury assessed with dynamic contrast-enhanced MRI

Introduction: The presence of an arteriovenous malformation in the brain (bAVM) induces hemodynamic changes, namely chronic hypoperfusion, loss of autoregulation and venous congestion, leading to blood-brain barrier (BBB) dysfunction. Conversely, bAVM treatment is thought to modify this longstanding...

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Principais autores: Leire Pedrosa, Alejandra Mosteiro, Marta Codes, Gloria Cabrera, Laura Aguado, Anna M. Planas, Sergio Amaro, Abraham Martin, Ana Rodríguez-Hernández, Ramon Torné
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-01-01
coleção:Brain and Spine
Assuntos:
Blood-brain barrier
Brain arteriovenous malformation
DCE-MRI
Reperfusion
Permeability
Rat model
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S277252942501690X
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