Inhibitory receptor expression depends more dominantly on differentiation and activation than exhaustion of human CD8 T cells

Under conditions of chronic antigen stimulation, such as persistent viral infection and cancer, CD8 T cells may diminish effector function, which has been termed exhaustion. Expression of inhibitory Receptors (iRs) is often regarded as a hallmark of exhaustion. Here we studied the expression of eigh...

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Principais autores:	Amandine eLegat, Daniel E Speiser, Hanspeter ePircher, Dietmar eZehn, Silvia A Fuertes Marraco
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2013-12-01
Serija:	Frontiers in Immunology
Teme:	differentiation activation CD8 T cells inhibitory receptors t cell exhaustion
Online dostop:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00455/full
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