Intron-Encoded Domain of Herstatin, An Autoinhibitor of Human Epidermal Growth Factor Receptors, Is Intrinsically Disordered

Human epidermal growth factor receptors (HER/ERBB) form dimers that promote cell proliferation, migration, and differentiation, but overexpression of HER proteins results in cancer. Consequently, inhibitors of HER dimerization may function as effective antitumor drugs. An alternatively spliced varia...

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Principais autores:	Daisuke Tashiro, Shunji Suetaka, Nao Sato, Koji Ooka, Tomoko Kunihara, Hisashi Kudo, Junichi Inatomi, Yuuki Hayashi, Munehito Arai
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Molecular Biosciences
Assuntos:	human epidermal growth factor receptor herstatin intron-encoded protein intrinsically disordered protein pre-molten globule state small-angle X-ray scattering
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.862910/full
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