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Nexus of IDO1/Kynurenine Pathway to T-Cell Exhaustion: Hypoxia-Induced Tryptophan Metabolism in Glioblastoma

Glioblastoma (GBM) is a universally fatal cancer for which the standard of care has remained largely unchanged for the last 20 years. Recent work has demonstrated that most therapeutic trials for GBM fail due to complex mechanisms of immunosuppression mediated by both the innate and adaptive immune...

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Principais autores: Matthew Abikenari, George Nageeb, Joseph H. Ha, Matthew Adam Sjoholm, Justin Liu, Brandon Bergsneider, Jocelyn Valenzuela, James Poe, Kwang Bog Cho, Rohit Verma, Caren Wu, Vivek Sanker, Ravi Medikonda, Lily H. Kim, John Choi, Matei A. Banu, Michael Lim
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-03-01
Serier:Metabolites
Fag:
glioblastoma
immunometabolism
tryptophan–kynurenine pathway
IDO1/TDO2
hypoxia (HIF-1α/HIF-2α)
GCN2–AHR signaling
Online adgang:https://www.mdpi.com/2218-1989/16/3/185
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