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In vitro mimicking of humanized cardiogenesis under porcine condition

Abstract Background One promising strategy to generate humanized organs is through embryo complementation by injecting human pluripotent stem cells (PSCs) into gene-edited porcine embryos. This strategy is predicated on how human cells adapt to a porcine environment, which has a body temperature of...

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Main Authors: Jiajun Li, Changjiang Xu, Bingbo Shi, Yawen Lyu, Zejie Lin, Wei Shi, Jiachen Xu, Xinle Zou, Xiaomin Wang, Hanqing Zhao, Chengchen Zhao, Duanqing Pei
Format: Artigo
Language:Inglês
Published: BMC 2026-01-01
Series:Cell & Bioscience
Subjects:
iPSCs
Interspecies chimerism
Pig
Cardiac differentiation
Organogenesis
Online Access:https://doi.org/10.1186/s13578-025-01521-8
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