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Efficient generation of human dorsal spinal GABAergic progenitors for the treatment of spinal cord injury

Abstract Traumatic spinal cord injury (SCI) induces rapid necrotic cell death, leading to severe neuronal and glial loss. A critical consequence is the disruption of γ-aminobutyric acid (GABA)ergic inhibitory tone in the dorsal horn, which results in excessive glutamate release and neuronal hyperexc...

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Príomhchruthaitheoirí: Xianglan Feng, Yutong Wan, Minxian Peng, Yan-Ting Cheung, Zhinan Lin, Kin-Wai Tam, Chaoyang Fan, Yongting Yang, Dengcheng Zhan, Huazhang Zhu, Ying Yu, Xifeng Wang, Qiang Liu, Xiaowei Zhu, Ying-Shing Chan, Martin Cheung, Chi-Wai Cheung, Jessica Aijia Liu
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Publishing Group 2026-03-01
Sraith:Experimental and Molecular Medicine
Rochtain ar líne:https://doi.org/10.1038/s12276-026-01665-8
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