Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen
We set out to develop scalable assays to measure bacterial adhesion to mammalian extracellular matrix proteins, with the aim to perform high-throughput screening for inhibitors. Our model system is the trimeric autotransporter adhesin YadA from Yersinia enterocolitica that binds to collagen.Using ba...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2019-12-01
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| Schriftenreihe: | The Cell Surface |
| Online-Zugang: | http://www.sciencedirect.com/science/article/pii/S2468233018300422 |
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