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CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis

Summary: Ferroptosis is an iron-dependent cell death mechanism characterized by the accumulation of toxic lipid peroxides and cell membrane rupture. GPX4 (glutathione peroxidase 4) prevents ferroptosis by reducing these lipid peroxides into lipid alcohols. Ferroptosis induction by GPX4 inhibition ha...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Kamakoti P. Bhat, Jinchu Vijay, Caroline K. Vilas, Jyoti Asundi, Jun Zou, Ted Lau, Xiaoyu Cai, Musaddeque Ahmed, Michal Kabza, Julie Weng, Jean-Philippe Fortin, Aaron Lun, Steffen Durinck, Marc Hafner, Michael R. Costa, Xin Ye
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-06-01
Schriftenreihe:Cell Reports
Schlagworte:
CP: Molecular biology
CP: Cancer
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124724006739
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