Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis

La Crosse virus (LACV) is a major cause of pediatric encephalitis and aseptic meningitis in the Midwestern, Mid-Atlantic, and Southern United States, where it is an emerging pathogen. The LACV Gc glycoprotein plays a critical role in the neuropathogenesis of LACV encephalitis as the putative virus a...

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Egile Nagusiak:	Bradley S. Hollidge, Mary-Virginia Salzano, John M. Ibrahim, Jonathan W. Fraser, Valentina Wagner, Nicole E. Leitner, Susan R. Weiss, Friedemann Weber, Francisco González-Scarano, Samantha S. Soldan
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2022-07-01
Saila:	Viruses
Gaiak:	La Crosse virus fusion peptide viral encephalitis neuroinvasion orthobunyavirus <i>Bunyavirales</i>
Sarrera elektronikoa:	https://www.mdpi.com/1999-4915/14/7/1464
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