Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression.
BACKGROUND:Insulators and domain boundaries both shield genes from adjacent enhancers and inhibit intrusion of heterochromatin into transgenes. Previous studies examined the functional mechanism of the MYC insulator element MINE and its CTCF binding sites in the context of transgenes that were rando...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2009-07-01
|
| Colección: | PLoS ONE |
| Acceso en línea: | http://europepmc.org/articles/PMC2699473?pdf=render |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|